| Entry |
|
|---|
| Name |
Naltrexone (USAN/INN);
Vivitrol (TN) |
|---|
| Product |
|
|---|
| Formula |
C20H23NO4
|
|---|
| Exact mass |
341.1627
|
|---|
| Mol weight |
341.4009
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Analgesic
DG01586 Opioid receptor antagonist
|
|---|
| Remark |
| Product (DG00997): | D05113<US> D02095<US> |
| Product (mixture): | D10751<US> |
|
|---|
| Efficacy |
Antialcohol dependence, Narcotic antagonist, Opioid receptor antagonist |
|---|
| Disease |
Alcohol Dependence [DS: H01611] |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Structure map |
| map07224 | Opioid receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N07 OTHER NERVOUS SYSTEM DRUGS
N07B DRUGS USED IN ADDICTIVE DISORDERS
N07BB Drugs used in alcohol dependence
N07BB04 Naltrexone
D05113 Naltrexone (USAN/INN) <US>
USP drug classification [BR:br08302]
Anti-Addiction/Substance Abuse Treatment Agents
Alcohol Deterrents/Anti-craving
Naltrexone
D05113 Naltrexone (USAN/INN)
Opioid Dependence
Naltrexone
D05113 Naltrexone (USAN/INN)
Drug groups [BR:br08330]
Analgesic
DG01586 Opioid receptor antagonist
DG00997 Naltrexone
D05113 Naltrexone
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D05113 Naltrexone (USAN/INN) <US>
OPRK1
D05113 Naltrexone (USAN/INN) <US>
OPRD1
D05113 Naltrexone (USAN/INN) <US>
Drug groups [BR:br08330]
Analgesic
DG01586 Opioid receptor antagonist
DG00997 Naltrexone
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 25
1 C1z C 46.6394 -16.7446
2 C8y C 46.6394 -15.4129
3 C1z C 47.8309 -17.4454
4 C1y C 45.5180 -17.3753
5 C1x C 47.8309 -16.1138
6 C8y C 45.5180 -14.7821
7 C8y C 47.8309 -14.7821
8 C1y C 48.9523 -16.7446
9 C1x C 47.8309 -18.7070
10 O2x O 44.2564 -16.0437
11 C5x C 45.5180 -18.7070
12 C1x C 50.0737 -16.1138
13 C8y C 45.5180 -13.4504
14 C1x C 48.9523 -15.4830
15 C8x C 47.8309 -13.4504
16 N1y N 50.0737 -17.4454
17 C1x C 46.6394 -19.4079
18 C8x C 46.7095 -12.8196
19 O1a O 44.4667 -12.8196
20 O1a O 49.0924 -18.3566
21 C1b C 51.4754 -17.4454
22 C1y C 52.1763 -18.6369
23 C1x C 52.1241 -20.0403
24 C1x C 53.3435 -19.3117
25 O5x O 44.2872 -19.3893
BOND 30
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1 #Up
5 2 6 2
6 2 7 1
7 3 8 1
8 3 9 1
9 4 10 1 #Down
10 4 11 1
11 5 12 1
12 6 13 1
13 7 14 1
14 7 15 2
15 8 16 1 #Up
16 9 17 1
17 13 18 2
18 13 19 1
19 6 10 1
20 8 14 1
21 11 17 1
22 12 16 1
23 15 18 1
24 3 20 1 #Up
25 16 21 1
26 21 22 1
27 22 23 1
28 22 24 1
29 23 24 1
30 11 25 2
|
|---|
